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Target
Histone deacetylase 11
Ligand
BDBM587556
Substrate
n/a
Meas. Tech.
In Vitro Histone Deacetylase Assay I
IC50
<500±n/a nM
Citation
 Zheng, X; Martin, MW; Ng, PY; Thomason, JR; Han, B; Rudnitskaya, A; Lancia, Jr., DR Isoindolines as HDAC inhibitors US Patent  US11535607 Publication Date 12/27/2022 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM587556
Synonyms:
(S)-N-hydroxy-2-(6-(trifluoromethyl)- 4,5,6,7-tetrahydro-1H- benzo[d]imidazol-2-yl)isoindoline-4- carboxamide | US11535607, Example 2-2
Type:
Small organic molecule
Emp. Form.:
C17H17F3N4O2
Mol. Mass.:
366.3377
SMILES:
ONC(=O)c1cccc2CN(Cc12)c1nc2CC[C@@H](Cc2[nH]1)C(F)(F)F |r|
Structure:
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