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Target
Histone deacetylase 11
Ligand
BDBM587591
Substrate
n/a
Meas. Tech.
In Vitro Histone Deacetylase Assay I
IC50
<500±n/a nM
Citation
 Zheng, X; Martin, MW; Ng, PY; Thomason, JR; Han, B; Rudnitskaya, A; Lancia, Jr., DR Isoindolines as HDAC inhibitors US Patent  US11535607 Publication Date 12/27/2022 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Human
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM587591
Synonyms:
N-hydroxy-1,1-dimethyl-2- (oxazolo[4,5-c]pyridin-2-yl)isoindoline- 4-carboxamide | US11535607, Example 21-1
Type:
Small organic molecule
Emp. Form.:
C17H16N4O3
Mol. Mass.:
324.3339
SMILES:
CC1(C)N(Cc2c1cccc2C(=O)NO)c1nc2cnccc2o1
Structure:
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