Reaction Details
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Histone deacetylase 11
Ligand
BDBM50273538
Substrate
n/a
Meas. Tech.
In Vitro Histone Deacetylase Assay I
IC50
<500±n/a nM
Citation
Zheng, X; Martin, MW; Ng, PY; Thomason, JR; Han, B; Rudnitskaya, A; Lancia, Jr., DR Isoindolines as HDAC inhibitors US Patent US11535607 Publication Date 12/27/2022 More Info.:
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
Inhibitor
Name:
BDBM50273538
Synonyms:
CHEMBL4127894 | US11535607, Example 22-6
Type:
Small organic molecule
Emp. Form.:
C16H15F3N4O2
Mol. Mass.:
352.3111
SMILES:
CC1(C)N(Cc2c1cccc2C(=O)NO)c1ncc(cn1)C(F)(F)F
Structure:
