Reaction Details Report a problem with these data
Target
Histone deacetylase 11
Ligand
BDBM587615
Substrate
n/a
Meas. Tech.
In Vitro Histone Deacetylase Assay I
IC50
<500±n/a nM
Citation
 Zheng, X; Martin, MW; Ng, PY; Thomason, JR; Han, B; Rudnitskaya, A; Lancia, Jr., DR Isoindolines as HDAC inhibitors US Patent  US11535607 Publication Date 12/27/2022 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM587615
Synonyms:
N-hydroxy-1-oxo-2-(5- (trifluoromethyl)benzo[d]oxazol-2- yl)isoindoline-4-carboxamide; and | US11535607, Example 36-2
Type:
Small organic molecule
Emp. Form.:
C17H10F3N3O4
Mol. Mass.:
377.2742
SMILES:
ONC(=O)c1cccc2C(=O)N(Cc12)c1nc2cc(ccc2o1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: