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Target
Casein kinase I isoform alpha
Ligand
BDBM636483
Substrate
n/a
Meas. Tech.
CSNK1A1 Assay 2
IC50
3.00±n/a nM
Citation
 Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Rauh, U; Bömer, U; Hillig, R; Lechner, C; Mortier, JX; Sülzle, D; Kaulfuss, S; Corsello, S; Handing, K; Caliman, A; Madec, A SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF US Patent  US20230365554 Publication Date 11/16/2023 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM636483
Synonyms:
(2RS)-4,4-difluoro-2-(4-fluorophenyl)-N-{4-[(7RS)-5-methyl-4-oxo-3-[(1,3-thiazol-4-yl)amino]-7-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}butanamide (Mixture of 4 Stereoisomers) | US20230365554, Example 52 | US20230365554, Example 53 | US20230365554, Example 54 | US20230365554, Example 55 | US20230365554, Example 56
Type:
Small organic molecule
Emp. Form.:
C28H24F6N6O2S
Mol. Mass.:
622.585
SMILES:
CN1CC(CC(F)(F)F)c2[nH]c(c(Nc3cscn3)c2C1=O)-c1ccnc(NC(=O)C(CC(F)F)c2ccc(F)cc2)c1
Structure:
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