Reaction Details
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Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM647678
Substrate
n/a
Meas. Tech.
RIPK1-ADP-Glo Enzymatic Assay
EC50
263±n/a nM
Citation
Chen, JL; Chen, Y; DiMauro, EF; Liu, M; Methot, JL; Musacchio, AJ; Palani, A; Pio, B; Duque, LR; Siliphaivanh, P; Vara, BA RIPK1 INHIBITORS AND METHODS OF USE US Patent US20240025912 Publication Date 1/25/2024 More Info.:
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Human
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
Inhibitor
Name:
BDBM647678
Synonyms:
3-((5S,7R)-5-(3,5-difluorophenyl)-7- methyl-3-oxo-6,7-dihydro-3H- pyrrolo[2,1-c][1,2,4]triazol-2(5H)- yl)bicyclo[1.1.1]pentane-1-carbonitrile | US20240025912, Compound 1-69
Type:
Small organic molecule
Emp. Form.:
C18H16F2N4O
Mol. Mass.:
342.3426
SMILES:
C[C@@H]1C[C@@H](c2cc(F)cc(F)c2)n2c1nn(c2=O)C12CC(C1)(C2)C#N |r|
Structure:
