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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Ligand
BDBM14227
Substrate
BDBM13466
Meas. Tech.
Enzymatic Assay
Temperature
298.15±n/a K
Ki
37000±n/a nM
Comments
extracted
Citation
 Moretto, AF; Kirincich, SJ; Xu, WX; Smith, MJ; Wan, ZK; Wilson, DP; Follows, BC; Binnun, E; Joseph-McCarthy, D; Foreman, K; Erbe, DV; Zhang, YL; Tam, SK; Tam, SY; Lee, J Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem 14:2162-77 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Synonyms:
PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
34670.65
Organism:
Homo sapiens (Human)
Description:
The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.
Residue:
298
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
  
Inhibitor
Name:
BDBM14227
Synonyms:
3-(carboxymethoxy)-7-methyl-1-benzothiophene-2-carboxylic acid | benzothiophene 17
Type:
Small organic molecule
Emp. Form.:
C12H10O5S
Mol. Mass.:
266.27
SMILES:
Cc1cccc2c(OCC(O)=O)c(sc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM13466
Synonyms:
4-Nitrophenyl phosphate disodium salt hexahydrate | 4-nitrophenyl phosphate (pNPP) | disodium (4-nitrophenyl) phosphate | para-nitrophenyl phosphate (pNPP)
Type:
Small organic molecule
Emp. Form.:
C6H4NO6P
Mol. Mass.:
217.0739
SMILES:
[O-][N+](=O)c1ccc(O[P+]([O-])([O-])[O-])cc1
Structure:
Search PDB for entries with ligand similarity: