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Target
Cyclin-C
Ligand
BDBM50241863
Substrate
n/a
Meas. Tech.
ChEMBL_1670926 (CHEMBL4020955)
IC50
4.5±n/a nM
Citation
 Fujimoto, J; Hirayama, T; Hirata, Y; Hikichi, Y; Murai, S; Hasegawa, M; Hasegawa, Y; Yonemori, K; Hata, A; Aoyama, K; Cary, DR Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential. Bioorg Med Chem 25:3018-3033 (2017) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50241863
Synonyms:
CHEMBL4060561
Type:
Small organic molecule
Emp. Form.:
C23H22F3N5O
Mol. Mass.:
441.4489
SMILES:
Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CN(CC(F)(F)F)CCc2c1
Structure:
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