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Target
Tyrosine-protein kinase Fer
Ligand
BDBM50501959
Substrate
n/a
Meas. Tech.
ChEMBL_1806175 (CHEMBL4305534)
IC50
10.0±n/a nM
Citation
 Taniguchi, T; Inagaki, H; Baba, D; Yasumatsu, I; Toyota, A; Kaneta, Y; Kiga, M; Iimura, S; Odagiri, T; Shibata, Y; Ueda, K; Seo, M; Shimizu, H; Imaoka, T; Nakayama, K Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. ACS Med Chem Lett 10:737-742 (2019) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fer
Synonyms:
FER | FER_HUMAN | TYK3
Type:
Enzyme
Mol. Mass.:
94643.38
Organism:
Homo sapiens (Human)
Description:
P16591
Residue:
822
Sequence:
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
  
Inhibitor
Name:
BDBM50501959
Synonyms:
CHEMBL4557212
Type:
Small organic molecule
Emp. Form.:
C20H24N6O
Mol. Mass.:
364.4442
SMILES:
Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3cn[nH]c(=O)c23)c1 |r|
Structure:
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