Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50485941
Substrate
n/a
Meas. Tech.
ChEMBL_878927 (CHEMBL2185078)
IC50
6490±n/a nM
Citation
 Cosentino, L; Redondo-Horcajo, M; Zhao, Y; Santos, AR; Chowdury, KF; Vinader, V; Abdallah, QM; Abdel-Rahman, H; Fournier-Dit-Chabert, J; Shnyder, SD; Loadman, PM; Fang, WS; Díaz, JF; Barasoain, I; Burns, PA; Pors, K Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties. J Med Chem 55:11062-6 (2012) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50485941
Synonyms:
CHEMBL2181004
Type:
Small organic molecule
Emp. Form.:
C28H31NO6
Mol. Mass.:
477.5488
SMILES:
COc1ccc(CN[C@H]2CCc3cc(OC)c(OC)c(OC)c3-c3ccc(OC)c(=O)cc23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: