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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50049729
Substrate
n/a
Meas. Tech.
ChEMBL_31936 (CHEMBL642978)
IC50
62±n/a nM
Citation
 Ishii, A; Kotani, T; Nagaki, Y; Shibayama, Y; Toyomaki, Y; Okukado, N; Ienaga, K; Okamoto, K Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids. J Med Chem 39:1924-7 (1996) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50049729
Synonyms:
CHEMBL292887 | [3-(3-Nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C12H9N3O7
Mol. Mass.:
307.2158
SMILES:
OC(=O)CN1C(=O)N(Cc2cccc(c2)[N+]([O-])=O)C(=O)C1=O
Structure:
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