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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM8126
Substrate
n/a
Meas. Tech.
ChEMBL_1825411 (CHEMBL4325175)
IC50
20±n/a nM
Citation
 Tear, WF; Bag, S; Diaz-Gonzalez, R; Ceballos-Pérez, G; Rojas-Barros, DI; Cordon-Obras, C; Pérez-Moreno, G; García-Hernández, R; Martinez-Martinez, MS; Ruiz-Perez, LM; Gamarro, F; Gonzalez Pacanowska, D; Caffrey, CR; Ferrins, L; Manzano, P; Navarro, M; Pollastri, MP Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- J Med Chem 63:756-783 (2020) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM8126
Synonyms:
N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine | pyrazolo[1,5-b]pyridazine deriv. 16
Type:
Small organic molecule
Emp. Form.:
C16H12N6
Mol. Mass.:
288.3067
SMILES:
N(c1ccccc1)c1nccc(n1)-c1cnn2ncccc12
Structure:
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