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Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50033422
Substrate
n/a
Meas. Tech.
ChEMBL_1842623 (CHEMBL4343050)
Ki
1.4±n/a nM
Citation
 Kersten, C; Fleischer, E; Kehrein, J; Borek, C; Jaenicke, E; Sotriffer, C; Brenk, R How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using  J Med Chem 63:2095-2113 (2020) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
Glycylpeptide N-tetradecanoyltransferase | N-myristoyltransferase (NMT1)
Type:
Protein
Mol. Mass.:
48514.36
Organism:
Leishmania major
Description:
Q4Q5S8
Residue:
421
Sequence:
MSRNPSNSDAAHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVML
  
Inhibitor
Name:
BDBM50033422
Synonyms:
CHEMBL3357688
Type:
Small organic molecule
Emp. Form.:
C22H26Cl2N6O2S
Mol. Mass.:
509.452
SMILES:
CN1CCN(CC1)c1cc(ccn1)-c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1c(C)nn(C)c1C
Structure:
Search PDB for entries with ligand similarity: