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Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50364113
Substrate
n/a
Meas. Tech.
ChEMBL_1842628 (CHEMBL4343055)
Ki
14±n/a nM
Citation
 Kersten, C; Fleischer, E; Kehrein, J; Borek, C; Jaenicke, E; Sotriffer, C; Brenk, R How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using  J Med Chem 63:2095-2113 (2020) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
Glycylpeptide N-tetradecanoyltransferase | N-myristoyltransferase (NMT1)
Type:
Protein
Mol. Mass.:
48514.36
Organism:
Leishmania major
Description:
Q4Q5S8
Residue:
421
Sequence:
MSRNPSNSDAAHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVML
  
Inhibitor
Name:
BDBM50364113
Synonyms:
CHEMBL1230468
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2N6O2S
Mol. Mass.:
495.425
SMILES:
Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Structure:
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