Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50080120
Substrate
n/a
Meas. Tech.
ChEBML_72494
IC50
130±n/a nM
Citation
 Long, YQ; Voigt, JH; Lung, FD; King, CR; Roller, PP Significant compensatory role of position Y-2 conferring high affinity to non-phosphorylated inhibitors of Grb2-SH2 domain. Bioorg Med Chem Lett 9:2267-72 (1999) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50080120
Synonyms:
CHEMBL409686 | Cyclo peptide analogue
Type:
Small organic molecule
Emp. Form.:
C55H79N12O21PS2
Mol. Mass.:
1339.387
SMILES:
CSCC[C@H]1NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CCC(O)=O)NC(=O)CSC[C@@H](NC(=O)[C@@H](Cc2ccc(OP(O)(O)=O)cc2)NC1=O)C(N)=O)C(C)C
Structure:
Search PDB for entries with ligand similarity: