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Found 964 with Last Name = 'voigt' and Initial = 'jh'
TargetBeta-secretase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392835(CHEMBL2151181)
Affinity DataKi: <1nMAssay Description:Inhibition of human recombinant BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392835(CHEMBL2151181)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392836(CHEMBL2151141)
Affinity DataKi:  7.80nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392837(CHEMBL2151182)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392838(CHEMBL2151179)
Affinity DataKi:  33nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392839(CHEMBL2151180)
Affinity DataKi:  47nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392840(CHEMBL2151138)
Affinity DataKi:  57nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392841(CHEMBL2151139)
Affinity DataKi:  88nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392842(CHEMBL2151140)
Affinity DataKi:  210nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392843(CHEMBL1233206)
Affinity DataKi:  270nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392844(CHEMBL2151134)
Affinity DataKi:  350nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392845(CHEMBL2151135)
Affinity DataKi:  670nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232469(CHEMBL252145 | N,N-bis(tosylmethyl)hexan-1-amine)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232467(CHEMBL399303 | phenyl-N,N-bis(tosylmethyl)methanam...)
Affinity DataKi:  7.50E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232470(2-phenyl-N,N-bis(o-tolylthiomethyl)ethanamine | CH...)
Affinity DataKi:  7.50E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232468(6-(((3-chlorobenzyl)(methyl)amino)methyl)-N2-o-tol...)
Affinity DataKi:  7.80E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232466(2-(dimethylamino)ethyl 4-(5-(4-methoxybenzylidene)...)
Affinity DataKi:  8.10E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392846(CHEMBL2151136)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232465(4-methoxy-benzoic acid 2-diethylaminomethyl-4-(1,1...)
Affinity DataKi:  1.13E+4nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232464(CHEMBL251947 | {3-[2-(4-bromo-phenyl)-benzo[d]imid...)
Affinity DataKi:  1.19E+4nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nih

Curated by ChEMBL
LigandPNGBDBM50132237(CHEMBL320852 | [Difluoro-(6-methanesulfonylaminoca...)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232471(CHEMBL251948 | N-(3-(benzyl(isopropyl)amino)propyl...)
Affinity DataKi:  2.09E+4nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392847(CHEMBL2151040)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nih

Curated by ChEMBL
LigandPNGBDBM50103227(6-(Difluoro-phosphono-methyl)-naphthalene-2-carbox...)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392848(CHEMBL2151137)
Affinity DataKi:  4.40E+4nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Nih

Curated by ChEMBL
LigandPNGBDBM50075312((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...)
Affinity DataKi:  1.79E+5nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50085869(CHEMBL367037 | N-[1-(1-{2-Carbamoyl-1-[3-(5-methyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476438(CHEMBL233298)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50073909(CHEMBL72036 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476450(CHEMBL233724)
Affinity DataIC50:  4nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476437(CHEMBL398137)
Affinity DataIC50:  7nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50075017(CHEMBL332862 | Phosphoric acid mono-[4-((R)-2-acet...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration of the compound against Growth factor receptor bound protein 2 in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50085874(2-{4-[(S)-2-(1-{(S)-2-Carbamoyl-1-[3-(5-methyl-ind...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Growth factor receptor bound protein 2 binding by ELISA assay methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476456(CHEMBL233928)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476443(CHEMBL392993)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476452(CHEMBL391522)
Affinity DataIC50:  10nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565259(US11414416, Compound D1 | US11560381, Compound D1)
Affinity DataIC50: >10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565260(4-(2-[1-[2-([[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-...)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565262(US11414416, Compound D3 | US11560381, Compound D3 ...)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565263(US11414416, Compound D4 | US11560381, Compound D4)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565264(N-(1-[[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro...)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565265(US11414416, Compound D6 | US11560381, Compound D6)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565266(US11414416, Compound D7 | US11560381, Compound D7)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565267(US11414416, Compound D8 | US11560381, Compound D8)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565268(US11414416, Compound D9 | US11560381, Compound D9)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565269(US11414416, Compound D10 | US11560381, Compound D1...)
Affinity DataIC50: >10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565270((2S)-1-[[2,6-dimethoxy-4-(2-methyl-1-oxo-2,7-napht...)
Affinity DataIC50: >10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565271(1-[[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,...)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565272(1-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7...)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM565273(1,2-dihydro-2,7-naphthyridin-4-yl)phenyl]methyl]-N...)
Affinity DataIC50: <10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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