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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50232465
Substrate
n/a
Meas. Tech.
ChEMBL_461005 (CHEMBL944961)
Ki
11300±n/a nM
Citation
 Cavasotto, CN; Orry, AJ; Murgolo, NJ; Czarniecki, MF; Kocsi, SA; Hawes, BE; O'Neill, KA; Hine, H; Burton, MS; Voigt, JH; Abagyan, RA; Bayne, ML; Monsma, FJ Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening. J Med Chem 51:581-8 (2008) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50232465
Synonyms:
4-methoxy-benzoic acid 2-diethylaminomethyl-4-(1,1-dioxo-1H-1lambda6-benzo[d]isothiazol-3-ylamino)-phenyl ester | CHEMBL399302
Type:
Small organic molecule
Emp. Form.:
C26H27N3O5S
Mol. Mass.:
493.575
SMILES:
CCN(CC)Cc1cc(ccc1OC(=O)c1ccc(OC)cc1)N=C1NS(=O)(=O)c2ccccc12 |w:23.24|
Structure:
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