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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50085946
Substrate
n/a
Meas. Tech.
ChEMBL_154462 (CHEMBL756965)
IC50
27000±n/a nM
Citation
 Malamas, MS; Sredy, J; Gunawan, I; Mihan, B; Sawicki, DR; Seestaller, L; Sullivan, D; Flam, BR New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties. J Med Chem 43:995-1010 (2000) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_RAT | PTP-1B | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Ptpn1 | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
49669.91
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
432
Sequence:
MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLELENLATQEAREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESRAPSIAVHSMSSMSQDTEVRKRMVGGGLQSAQASVPTEEELSPTEEEQKAHRPVHWKPFLVNVCMATALATGAYLCYRVCFH
  
Inhibitor
Name:
BDBM50085946
Synonyms:
2-(3-(4-Chloro-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-allyl)-[1,2,4]oxadiazolidine-3,5-dione | CHEMBL266474
Type:
Small organic molecule
Emp. Form.:
C29H21ClF3N3O5
Mol. Mass.:
583.942
SMILES:
Cc1oc(nc1COc1cccc(c1)C(=C\Cn1oc(=O)[nH]c1=O)\c1ccc(Cl)cc1)-c1ccc(cc1)C(F)(F)F
Structure:
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