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Target
Beta-2 adrenergic receptor
Ligand
BDBM50086666
Substrate
n/a
Meas. Tech.
ChEMBL_38611 (CHEMBL652294)
Ki
2.7±n/a nM
Citation
 Cecchetti, V; Schiaffella, F; Tabarrini, O; Fravolini, A (1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents. Bioorg Med Chem Lett 10:465-8 (2000) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2_CANLF
Type:
PROTEIN
Mol. Mass.:
46593.67
Organism:
Dog
Description:
ChEMBL_56504
Residue:
415
Sequence:
MGQPANRSVFLLAPNGSHAPDQGDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAKETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQLQKIDRSEGRFHAQNLSQVEQDGRSGHGHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSNNSNSRSDYAGEHSGCHLGQEKDSELLCEDPPGTEDRQGTVPSDSVDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50086666
Synonyms:
8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-4H-benzo[1,4]thiazin-3-one | CHEMBL143463
Type:
Small organic molecule
Emp. Form.:
C29H42N4O4S
Mol. Mass.:
542.733
SMILES:
COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Structure:
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