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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50090147
Substrate
n/a
Meas. Tech.
ChEBML_159446
IC50
1.1±n/a nM
Citation
 Rano, TA; Cheng, Y; Huening, TT; Zhang, F; Schleif, WA; Gabryelski, L; Olsen, DB; Kuo, LC; Lin, JH; Xu, X; Olah, TV; McLoughlin, DA; King, R; Chapman, KT; Tata, JR Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library. Bioorg Med Chem Lett 10:1527-30 (2000) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50090147
Synonyms:
(S)-4-(3,4-Dichloro-benzyl)-1-[(2S,4R)-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide | CHEMBL37383
Type:
Small organic molecule
Emp. Form.:
C37H46Cl2N4O4
Mol. Mass.:
681.692
SMILES:
CC(C)(C)NC(=O)[C@@H]1CN(Cc2ccc(Cl)c(Cl)c2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12
Structure:
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