Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM50536642
Substrate
n/a
Meas. Tech.
ChEMBL_1933876 (CHEMBL4479528)
IC50
180±n/a nM
Citation
 Temple, KJ; Duvernay, MT; Young, SE; Wen, W; Wu, W; Maeng, JG; Blobaum, AL; Stauffer, SR; Hamm, HE; Lindsley, CW Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against ?-Thrombin. J Med Chem 59:7690-5 (2016) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM50536642
Synonyms:
CHEMBL4566669
Type:
Small organic molecule
Emp. Form.:
C22H16ClF3N4O3S
Mol. Mass.:
508.901
SMILES:
COc1nn2cc(nc2s1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12
Structure:
Search PDB for entries with ligand similarity: