Reaction Details Report a problem with these data
Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50457701
Substrate
n/a
Meas. Tech.
ChEMBL_1990744 (CHEMBL4624479)
IC50
172±n/a nM
Citation
 Hudson, AR; Santora, VJ; Petroski, RE; Almos, TA; Anderson, G; Barido, R; Basinger, J; Bellows, CL; Bookser, BC; Broadbent, NJ; Cabebe, C; Chai, CK; Chen, M; Chow, S; Chung, M; Heger, L; Danks, AM; Freestone, GC; Gitnick, D; Gupta, V; Hoffmaster, C; Kaplan, AP; Kennedy, MR; Lee, D; Limberis, J; Ly, K; Mak, CC; Masatsugu, B; Morse, AC; Na, J; Neul, D; Nikpur, J; Renick, J; Sebring, K; Sevidal, S; Tabatabaei, A; Wen, J; Xia, S; Yan, Y; Yoder, ZW; Zook, D; Peters, M; Breitenbucher, JG Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9
Type:
Enzyme Catalytic Domain
Mol. Mass.:
71066.17
Organism:
attus norvegicus (Rat)
Description:
Glycine-1-transporter 0 HUMAN::P28572
Residue:
638
Sequence:
MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50457701
Synonyms:
CHEMBL4207171
Type:
Small organic molecule
Emp. Form.:
C22H21N5O2
Mol. Mass.:
387.4344
SMILES:
CC(C)Oc1ccc(cc1C(=O)N1Cc2cn(nc2C1)-c1ccnc(C)c1)C#N
Structure:
Search PDB for entries with ligand similarity: