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Target
Sodium- and chloride-dependent glycine transporter 2
Ligand
BDBM50102692
Substrate
n/a
Meas. Tech.
ChEMBL_70976 (CHEMBL680554)
IC50
16±n/a nM
Citation
 Caulfield, WL; Collie, IT; Dickins, RS; Epemolu, O; McGuire, R; Hill, DR; McVey, G; Morphy, JR; Rankovic, Z; Sundaram, H The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem 44:2679-82 (2001) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 2
Synonyms:
GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
87438.56
Organism:
Homo sapiens (Human)
Description:
Glycine-2-transporter 0 HUMAN::Q9Y345
Residue:
797
Sequence:
MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
  
Inhibitor
Name:
BDBM50102692
Synonyms:
4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-3,5-dimethoxy-benzamide | 4-benzyloxy-N-(1-dimethylaminocyclopentylmethyl)-3,5-dimethoxybenzamide | CHEMBL88588 | ORG-25543
Type:
Small organic molecule
Emp. Form.:
C24H32N2O4
Mol. Mass.:
412.5219
SMILES:
COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C
Structure:
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