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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50546041
Substrate
n/a
Meas. Tech.
ChEMBL_2013838 (CHEMBL4667416)
EC50
630±n/a nM
Citation
 Amaudrut, J; Argiriadi, MA; Barth, M; Breinlinger, EC; Bressac, D; Broqua, P; Calderwood, DJ; Chatar, M; Cusack, KP; Gauld, SB; Jacquet, S; Kamath, RV; Kort, ME; Lepais, V; Luccarini, JM; Masson, P; Montalbetti, C; Mounier, L; Potin, D; Poupardin, O; Rouaud, S; Spitzer, L; Wallace, CD Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active ROR? inverse agonists. Bioorg Med Chem Lett 29:1799-1806 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50546041
Synonyms:
CHEMBL4800301
Type:
Small organic molecule
Emp. Form.:
C28H26Cl2N4O4S
Mol. Mass.:
585.501
SMILES:
CNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)c(COc2cccc3c(cc(C)nc23)-c2ccncc2)c1Cl |r|
Structure:
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