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Target
Histamine H3 receptor
Ligand
BDBM50112027
Substrate
n/a
Meas. Tech.
ChEBML_85849
Ki
37±n/a nM
Citation
 Aslanian, R; Mutahi, MW; Shih, NY; McCormick, KD; Piwinski, JJ; Ting, PC; Albanese, MM; Berlin, MY; Zhu, X; Wong, SC; Rosenblum, SB; Jiang, Y; West, R; She, S; Williams, SM; Bryant, M; Hey, JA Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template. Bioorg Med Chem Lett 12:937-41 (2002) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50112027
Synonyms:
CHEMBL172610 | Phenyl-carbamic acid 4-(1H-imidazol-4-ylmethyl)-benzyl ester
Type:
Small organic molecule
Emp. Form.:
C18H17N3O2
Mol. Mass.:
307.3465
SMILES:
O=C(Nc1ccccc1)OCc1ccc(Cc2cnc[nH]2)cc1
Structure:
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