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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50553520
Substrate
n/a
Meas. Tech.
ChEMBL_2046788 (CHEMBL4701487)
IC50
0.300000±n/a nM
Citation
 Barlaam, B; Boiko, S; Boyd, S; Dry, H; Gingipalli, L; Ikeda, T; Johnson, T; Kawatkar, S; Lorthioir, O; Pike, A; Pollard, H; Read, J; Su, Q; Wang, H; Wang, H; Wang, L; Wang, P; Edmondson, SD Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50553520
Synonyms:
CHEMBL4776734
Type:
Small organic molecule
Emp. Form.:
C22H25FN10O
Mol. Mass.:
464.4987
SMILES:
CNC(=O)c1nn(C)c2ccc(Nc3nccc(n3)-n3cc(N[C@H]4CNC[C@@H]4F)c(C)n3)cc12 |r|
Structure:
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