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Target
Histone deacetylase 1
Ligand
BDBM50114818
Substrate
n/a
Meas. Tech.
ChEMBL_87852 (CHEMBL701992)
IC50
600±n/a nM
Citation
 Woo, SH; Frechette, S; Abou Khalil, E; Bouchain, G; Vaisburg, A; Bernstein, N; Moradei, O; Leit, S; Allan, M; Fournel, M; Trachy-Bourget, MC; Li, Z; Besterman, JM; Delorme, D Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. J Med Chem 45:2877-85 (2002) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50114818
Synonyms:
2-Methyl-8-naphthalen-2-yl-8-oxo-octanoic acid hydroxyamide | CHEMBL95510 | N-hydroxy-2-methyl-8-(naphthalen-2-yl)-8-oxooctanamide
Type:
Small organic molecule
Emp. Form.:
C19H23NO3
Mol. Mass.:
313.3908
SMILES:
CC(CCCCCC(=O)c1ccc2ccccc2c1)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: