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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50126405
Substrate
n/a
Meas. Tech.
ChEBML_201611
IC50
71.0±n/a nM
Citation
Cywin, CL; Zhao, BP; McNeil, DW; Hrapchak, M; Prokopowicz, AS; Goldberg, DR; Morwick, TM; Gao, A; Jakes, S; Kashem, M; Magolda, RL; Soll, RM; Player, MR; Bobko, MA; Rinker, J; DesJarlais, RL; Winters, MP Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK). Bioorg Med Chem Lett 13:1415-8 (2003) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM50126405
Synonyms:
CHEMBL285889 | N*1*-(7-{4-[(2-Dimethylamino-ethyl)-methyl-amino]-phenyl}-[1,6]naphthyridin-5-yl)-propane-1,3-diamine | N1-(7-(4-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)-1,6-naphthyridin-5-yl)propane-1,3-diamine
Type:
Small organic molecule
Emp. Form.:
C22H30N6
Mol. Mass.:
378.5138
SMILES:
CN(C)CCN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1