Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50004952
Substrate
n/a
Meas. Tech.
ChEBML_69121
IC50
1000±n/a nM
Citation
 Wright, SW; Carlo, AA; Danley, DE; Hageman, DL; Karam, GA; Mansour, MN; McClure, LD; Pandit, J; Schulte, GK; Treadway, JL; Wang, IK; Bauer, PH 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett 13:2055-8 (2003) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_PIG | FBP | FBP1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36781.07
Organism:
Pig
Description:
Liver FBPase (P00636)
Residue:
338
Sequence:
MTDQAAFDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK
  
Inhibitor
Name:
BDBM50004952
Synonyms:
3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid | CHEMBL31344
Type:
Small organic molecule
Emp. Form.:
C12H9Cl2NO4
Mol. Mass.:
302.11
SMILES:
OC(=O)CCc1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O
Structure:
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