Reaction Details Report a problem with these data
Target
Pancreatic triacylglycerol lipase
Ligand
BDBM50138735
Substrate
n/a
Meas. Tech.
ChEMBL_152478 (CHEMBL760716)
IC50
>50000±n/a nM
Citation
 Ebdrup, S; Sørensen, LG; Olsen, OH; Jacobsen, P Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase. J Med Chem 47:400-10 (2004) [PubMed]  Article 
Target
Name:
Pancreatic triacylglycerol lipase
Synonyms:
LIPP_HUMAN | PL | PNLIP | Pancreatic lipase
Type:
PROTEIN
Mol. Mass.:
51157.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_527250
Residue:
465
Sequence:
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
  
Inhibitor
Name:
BDBM50138735
Synonyms:
(S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-one | 4-Isopropyl-3-methyl-2-((S)-3-methyl-piperidine-1-carbonyl)-2H-isoxazol-5-one | CHEMBL106126
Type:
Small organic molecule
Emp. Form.:
C14H22N2O3
Mol. Mass.:
266.3361
SMILES:
CC(C)c1c(C)n(oc1=O)C(=O)N1CCC[C@H](C)C1 |r|
Structure:
Search PDB for entries with ligand similarity: