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Target
Ubiquitin thioesterase OTUB1
Ligand
BDBM50591323
Substrate
n/a
Meas. Tech.
ChEMBL_2200009 (CHEMBL5112525)
IC50
0.420000±n/a nM
Citation
 Tan, L; Shan, H; Han, C; Zhang, Z; Shen, J; Zhang, X; Xiang, H; Lu, K; Qi, C; Li, Y; Zhuang, G; Chen, G; Tan, L Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem 65:13645-13659 (2022) [PubMed] 
Target
Name:
Ubiquitin thioesterase OTUB1
Synonyms:
3.4.19.12 | Deubiquitinating enzyme OTUB1 | OTB1 | OTU domain-containing ubiquitin aldehyde-binding protein 1 | OTU1 | OTUB1 | OTUB1_HUMAN | Otubain-1 | Ubiquitin-specific-processing protease OTUB1 | hOTU1
Type:
PROTEIN
Mol. Mass.:
31269.58
Organism:
Human
Description:
ChEMBL_119178
Residue:
271
Sequence:
MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLEALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLASFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHIHIIALAQALSVSIQVEYMDRGEGGTTNPHIFPEGSEPKVYLLYRPGHYDILYK
  
Inhibitor
Name:
BDBM50591323
Synonyms:
CHEMBL5173239
Type:
Small organic molecule
Emp. Form.:
C22H16ClFN2O4
Mol. Mass.:
426.825
SMILES:
CN1CC[C@H](C1)Oc1ccc(Cl)c(-c2nc3c(o2)C(=O)c2ccccc2C3=O)c1F |r|
Structure:
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