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Target
N-lysine methyltransferase KMT5A
Ligand
BDBM50086655
Substrate
n/a
Meas. Tech.
ChEMBL_2210860 (CHEMBL5123809)
IC50
370±n/a nM
Citation
 Menna, M; Fiorentino, F; Marrocco, B; Lucidi, A; Tomassi, S; Cilli, D; Romanenghi, M; Cassandri, M; Pomella, S; Pezzella, M; Del Bufalo, D; Zeya Ansari, MS; Toma?evi?, N; Mladenovi?, M; Viviano, M; Sbardella, G; Rota, R; Trisciuoglio, D; Minucci, S; Mattevi, A; Rotili, D; Mai, A Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
N-lysine methyltransferase KMT5A
Synonyms:
KMT5A | KMT5A_HUMAN | N-lysine methyltransferase SETD8 | PRSET7 | SET domain-containing protein 8 (SetD8) | SET07 | SET8 | SETD8
Type:
Enzyme
Mol. Mass.:
42919.11
Organism:
Homo sapiens (Human)
Description:
Q9NQR1
Residue:
393
Sequence:
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
  
Inhibitor
Name:
BDBM50086655
Synonyms:
2-Methyl-5-p-tolylamino-benzothiazole-4,7-dione | 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole | CHEMBL290904
Type:
Small organic molecule
Emp. Form.:
C15H12N2O2S
Mol. Mass.:
284.333
SMILES:
Cc1nc2c(s1)C(=O)C=C(Nc1ccc(C)cc1)C2=O |t:9|
Structure:
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