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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50167718
Substrate
n/a
Meas. Tech.
ChEMBL_305145 (CHEMBL832598)
IC50
190±n/a nM
Citation
 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett 15:2865-9 (2005) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50167718
Synonyms:
2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanone | 2-Benzenesulfonyl-1-(4-trifluoromethyl-phenyl)-ethanone | CHEMBL383146
Type:
Small organic molecule
Emp. Form.:
C15H11F3O3S
Mol. Mass.:
328.306
SMILES:
FC(F)(F)c1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Structure:
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