Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50177559
Substrate
n/a
Meas. Tech.
ChEMBL_349444 (CHEMBL865696)
Ki
107±n/a nM
Citation
Shi, Q; Ornstein, PL; Briner, K; Richardson, TI; Arnold, MB; Backer, RT; Buckmaster, JL; Canada, EJ; Doecke, CW; Hertel, LW; Honigschmidt, N; Hsiung, HM; Husain, S; Kuklish, SL; Martinelli, MJ; Mullaney, JT; O'Brien, TP; Reinhard, MR; Rothhaar, R; Shah, J; Wu, Z; Xie, C; Zgombick, JM; Fisher, MJ Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor. Bioorg Med Chem Lett 16:2341-6 (2006) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Human
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50177559
Synonyms:
CHEMBL379352 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(2-chlorophenyl)-2-(diethylamino)ethyl)piperazin-1-yl)-1-oxopropan-2-yl)-2-(isoindolin-1-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C35H43Cl2N5O2
Mol. Mass.:
636.654
SMILES:
CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1Cl