Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM601033
Substrate
n/a
Meas. Tech.
ChEMBL_2237108 (CHEMBL5151004)
IC50
6.5±n/a nM
Citation
 Bayle, EDSvensson, FAtkinson, BNSteadman, DWillis, NJWoodward, HLWhiting, PVincent, JPFish, PV Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. J Med Chem 64:4289-4311 (2021) [PubMed] 
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM
Type:
PROTEIN
Mol. Mass.:
55706.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116492
Residue:
496
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
  
Inhibitor
Name:
BDBM601033
Synonyms:
1-[2,4-dichloro-3-(trifluoromethyl)phenyl]triazole | US11634391, Compound 295
Type:
Small organic molecule
Emp. Form.:
C9H4Cl2F3N3
Mol. Mass.:
282.049
SMILES:
FC(F)(F)c1c(Cl)ccc(c1Cl)-n1ccnn1
Structure:
Search PDB for entries with ligand similarity: