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Target
Proteasome subunit beta type-5
Ligand
BDBM50185647
Substrate
n/a
Meas. Tech.
ChEMBL_361596 (CHEMBL868170)
Ki
>80000±n/a nM
Citation
 Basse, N; Papapostolou, D; Pagano, M; Reboud-Ravaux, M; Bernard, E; Felten, AS; Vanderesse, R Development of lipopeptides for inhibiting 20S proteasomes. Bioorg Med Chem Lett 16:3277-81 (2006) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
DOA3 | PRE2 | PRG1 | PSB5_YEAST | Proteasome Macropain subunit PRE2
Type:
PROTEIN
Mol. Mass.:
31634.72
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_946840
Residue:
287
Sequence:
MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG
  
Inhibitor
Name:
BDBM50185647
Synonyms:
(S)-2-((S)-6-amino-2-((S)-2-((2S,3R)-3-hydroxy-2-((S)-2-((2S,3R)-3-hydroxy-2-octanamidobutanamido)-3-methylbutanamido)butanamido)-3-phenylpropanamido)hexanamido)-3-phenylpropanoic acid | CHEMBL378865
Type:
Small organic molecule
Emp. Form.:
C45H69N7O10
Mol. Mass.:
868.0703
SMILES:
CCCCCCCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Structure:
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