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Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM50613281
Substrate
n/a
Meas. Tech.
ChEMBL_2291656
IC50
36±n/a nM
Citation
 Wilkinson, AJ; Ooi, N; Finlayson, J; Lee, VE; Lyth, D; Maskew, KS; Newman, R; Orr, D; Ansell, K; Birchall, K; Canning, P; Coombs, P; Fusani, L; McIver, E; Pisco, J; Ireland, PM; Jenkins, C; Norville, IH; Southern, SJ; Cowan, R; Hall, G; Kettleborough, C; Savage, VJ; Cooper, IR Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg Med Chem Lett 90:0 (2023) [PubMed] 
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
2.1.1.228 | M1G-methyltransferase | tRNA (guanine-N(1)-)-methyltransferase | tRNA [GM37] methyltransferase | trmD
Type:
PROTEIN
Mol. Mass.:
28417.50
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_120942
Residue:
255
Sequence:
MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
  
Inhibitor
Name:
BDBM50613281
Synonyms:
CHEMBL5270195
Type:
Small organic molecule
Emp. Form.:
C21H27N5O2
Mol. Mass.:
381.4714
SMILES:
[H][C@]12CC[C@]([H])(C[C@H](C1)N(C)C(=O)Cn1c(cc3cc(cnc13)C(N)=O)C1CC1)N2 |r|
Structure:
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