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Target
Poly [ADP-ribose] polymerase 2
Ligand
BDBM139658
Substrate
n/a
Meas. Tech.
ChEMBL_2292764
IC50
1.2±n/a nM
Citation
 Wang, YQ; Wang, PY; Wang, YT; Yang, GF; Zhang, A; Miao, ZH An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy. J Med Chem 59:9575-9598 (2016) [PubMed] 
Target
Name:
Poly [ADP-ribose] polymerase 2
Synonyms:
2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2)
Type:
n/a
Mol. Mass.:
63409.97
Organism:
Mouse
Description:
Alexis Biochemicals, Cat. no. ALX-201-064-C020
Residue:
559
Sequence:
MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNRDSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGKYDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKRAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTEKELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQYLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLRVAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSPNQVRMRYLLKIQFNFLQLW
  
Inhibitor
Name:
BDBM139658
Synonyms:
US8894989, 37
Type:
Small organic molecule
Emp. Form.:
C18H15N5O
Mol. Mass.:
317.3446
SMILES:
O=c1[nH]nc2[nH]c(CN3Cc4ccccc4C3)nc3cccc1c23
Structure:
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