Reaction Details Report a problem with these data
Target
Angiotensinogen
Ligand
BDBM50615602
Substrate
n/a
Meas. Tech.
ChEMBL_2303158
IC50
0.460000±n/a nM
Citation
 Alagarsamy, V; Chitra, K; Saravanan, G; Solomon, VR; Sulthana, MT; Narendhar, B An overview of quinazolines: Pharmacological significance and recent developments. Eur J Med Chem 151:628-685 (2018) [PubMed] 
Target
Name:
Angiotensinogen
Synonyms:
ANGT_RAT | Agt | Angiotensin | Serpina8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51974.87
Organism:
RAT
Description:
Angiotensin 0 RAT::P01015
Residue:
477
Sequence:
MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV
  
Inhibitor
Name:
BDBM50615602
Synonyms:
CHEMBL5278845
Type:
Small organic molecule
Emp. Form.:
C37H37N7O3
Mol. Mass.:
627.7348
SMILES:
CCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)OC(C)(C)C
Structure:
Search PDB for entries with ligand similarity: