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Target
Angiotensinogen
Ligand
BDBM50282703
Substrate
n/a
Meas. Tech.
ChEMBL_2303158
IC50
0.220000±n/a nM
Citation
 Alagarsamy, V; Chitra, K; Saravanan, G; Solomon, VR; Sulthana, MT; Narendhar, B An overview of quinazolines: Pharmacological significance and recent developments. Eur J Med Chem 151:628-685 (2018) [PubMed] 
Target
Name:
Angiotensinogen
Synonyms:
ANGT_RAT | Agt | Angiotensin | Serpina8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51974.87
Organism:
RAT
Description:
Angiotensin 0 RAT::P01015
Residue:
477
Sequence:
MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV
  
Inhibitor
Name:
BDBM50282703
Synonyms:
CHEMBL35638 | N-Benzyl-N-{2-ethyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-isonicotinamide
Type:
Small organic molecule
Emp. Form.:
C37H30N8O2
Mol. Mass.:
618.6865
SMILES:
CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: