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Target
Lipoprotein lipase
Ligand
BDBM50253977
Substrate
n/a
Meas. Tech.
ChEMBL_559993 (CHEMBL1018743)
IC50
>50000±n/a nM
Citation
 Goodman, KB; Bury, MJ; Cheung, M; Cichy-Knight, MA; Dowdell, SE; Dunn, AK; Lee, D; Lieby, JA; Moore, ML; Scherzer, DA; Sha, D; Suarez, DP; Murphy, DJ; Harpel, MR; Manas, ES; McNulty, DE; Annan, RS; Matico, RE; Schwartz, BK; Trill, JJ; Sweitzer, TD; Wang, DY; Keller, PM; Krawiec, JA; Jaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett 19:27-30 (2008) [PubMed]  Article 
Target
Name:
Lipoprotein lipase
Synonyms:
LIPL_RAT | Lpl
Type:
PROTEIN
Mol. Mass.:
53093.31
Organism:
Rattus norvegicus
Description:
ChEMBL_559993
Residue:
474
Sequence:
MESKALLLVALGVWLQSLTAFRGGVAAADGGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPEVATNKTYSFLIYTEVDIGELLMMKLKWKNDSYFRWSDWWSSPSFVIEKIRVKAGETQKKVIFCAREKVSHLQKGKDAAVFVKCHDKSLKKSG
  
Inhibitor
Name:
BDBM50253977
Synonyms:
1-(1-methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-5-yl)-3-phenylurea | CHEMBL462694
Type:
Small organic molecule
Emp. Form.:
C16H21N5O3S
Mol. Mass.:
363.435
SMILES:
Cn1nc(cc1NC(=O)Nc1ccccc1)S(=O)(=O)N1CCCCC1
Structure:
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