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Target
Endothelial lipase
Ligand
BDBM50254436
Substrate
n/a
Meas. Tech.
ChEMBL_559992 (CHEMBL1018742)
IC50
300±n/a nM
Citation
 Goodman, KB; Bury, MJ; Cheung, M; Cichy-Knight, MA; Dowdell, SE; Dunn, AK; Lee, D; Lieby, JA; Moore, ML; Scherzer, DA; Sha, D; Suarez, DP; Murphy, DJ; Harpel, MR; Manas, ES; McNulty, DE; Annan, RS; Matico, RE; Schwartz, BK; Trill, JJ; Sweitzer, TD; Wang, DY; Keller, PM; Krawiec, JA; Jaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett 19:27-30 (2008) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Human
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM50254436
Synonyms:
5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid dimethylamide | CHEMBL468282
Type:
Small organic molecule
Emp. Form.:
C14H17N3O4S
Mol. Mass.:
323.367
SMILES:
CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)c(C)o1
Structure:
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