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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50277565
Substrate
n/a
Meas. Tech.
ChEMBL_502053 (CHEMBL981264)
IC50
1250±n/a nM
Citation
 Dang, Q; Brown, BS; Liu, Y; Rydzewski, RM; Robinson, ED; van Poelje, PD; Reddy, MR; Erion, MD Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics. J Med Chem 52:2880-98 (2009) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_RAT | Fbp | Fbp1 | Fructose-1,6-bisphosphatase
Type:
PROTEIN
Mol. Mass.:
39605.40
Organism:
Rattus norvegicus
Description:
ChEMBL_595158
Residue:
363
Sequence:
MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNCGVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGNEDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICDELF
  
Inhibitor
Name:
BDBM50277565
Synonyms:
5-(6-amino-9-neopentyl-9H-purin-8-yl)furan-2-ylphosphonic acid | CHEMBL482735 | {5-[6-Amino-9-(2,2-dimethyl-propyl)-9H-purin-8-yl]-furan-2-yl}-phosphonic Acid
Type:
Small organic molecule
Emp. Form.:
C14H18N5O4P
Mol. Mass.:
351.2976
SMILES:
CC(C)(C)Cn1c(nc2c(N)ncnc12)-c1ccc(o1)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: