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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50277660
Substrate
n/a
Meas. Tech.
ChEMBL_502053 (CHEMBL981264)
IC50
4000±n/a nM
Citation
 Dang, Q; Brown, BS; Liu, Y; Rydzewski, RM; Robinson, ED; van Poelje, PD; Reddy, MR; Erion, MD Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics. J Med Chem 52:2880-98 (2009) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_RAT | Fbp | Fbp1 | Fructose-1,6-bisphosphatase
Type:
PROTEIN
Mol. Mass.:
39605.40
Organism:
Rattus norvegicus
Description:
ChEMBL_595158
Residue:
363
Sequence:
MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNCGVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGNEDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICDELF
  
Inhibitor
Name:
BDBM50277660
Synonyms:
CHEMBL483354 | {5-[6-Amino-9-(2,2-dimethyl-propyl)-2-methylsulfanyl-9H-purin-8-yl]-furan-2-yl}-phosphonic Acid
Type:
Small organic molecule
Emp. Form.:
C15H20N5O4PS
Mol. Mass.:
397.389
SMILES:
CSc1nc(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)(C)C)c2n1
Structure:
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