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Target
Type-2 angiotensin II receptor
Ligand
BDBM50031530
Substrate
n/a
Meas. Tech.
ChEBML_35430
IC50
920±n/a nM
Citation
Deprez, P; Guillaume, J; Corbier, A; Fortin, M; Vevert, JP; Heckmann, B Balanced AT1 and AT2 angiotensin II antagonists. II. Potent 5 α-hydroxyacid imidazolyl biphenyl sulfonylureas Bioorg Med Chem Lett 5:2611-2616 (1995) Article
More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
Inhibitor
Name:
BDBM50031530
Synonyms:
2-Butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazol-5-carboxylic acid Dipotassium salt | 5-alpha-hydroxyacid imidazolyl biphenyl sulfonyl urea analogue | CHEMBL80370 | potassium 2-butyl-4-(methylsulfanyl)-1-{[4-(2-{[(propylcarbamoyl)amino]sulfonyl}phenyl)phenyl]methyl}-1H-imidazole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H31N4O5S2
Mol. Mass.:
543.679
SMILES:
CCCCc1nc(SC)c(C([O-])=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCCC