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Target
Proteinase-activated receptor 1
Ligand
BDBM50292440
Substrate
n/a
Meas. Tech.
ChEMBL_546484 (CHEMBL1026653)
IC50
20000±n/a nM
Citation
 Gulavita, NK; Pomponi, SA; Wright, AE; Garay, M; Sills, MA Aplysillin A, a Thrombin Receptor Antagonist from the Marine Sponge Aplysina fistularis fulva J Nat Prod 58:954-957 (1995) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50292440
Synonyms:
Aplysiillin A | CHEMBL462733
Type:
Small organic molecule
Emp. Form.:
C16H10Br2O11S2
Mol. Mass.:
602.183
SMILES:
Oc1ccc(\C=C(\OS([O-])(=O)=O)/C(/OS([O-])(=O)=O)=C/c2cc(O)c(O)c(Br)c2)cc1Br
Structure:
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