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Target
Myelin-associated glycoprotein
Ligand
BDBM50327100
Substrate
n/a
Meas. Tech.
ChEMBL_663794 (CHEMBL1250694)
Kd
>800000±n/a nM
Citation
 Schwardt, O; Koliwer-Brandl, H; Zimmerli, R; Mesch, S; Rossato, G; Spreafico, M; Vedani, A; Kelm, S; Ernst, B Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein. Bioorg Med Chem 18:7239-51 (2010) [PubMed]  Article 
Target
Name:
Myelin-associated glycoprotein
Synonyms:
MAG_MOUSE | Mag | Siglec-4a
Type:
PROTEIN
Mol. Mass.:
69368.91
Organism:
Mus musculus
Description:
ChEMBL_663794
Residue:
627
Sequence:
MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESSSFSGGDNPHVLYSPEFRISGAPDKYESEKQRLGSERRLLGLRGESPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
  
Inhibitor
Name:
BDBM50327100
Synonyms:
CHEMBL1254194 | sodium(1R,3R,4R,5S)-5-acetamido-1-(benzyloxy)-3-(2-(4-chlorobenzamido)ethoxy)-4-(2-fluoroacetamido)cyclohexo-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C27H30ClFN3O7
Mol. Mass.:
562.995
SMILES:
CC(=O)N[C@H]1C[C@](C[C@@H](OCCNC(=O)c2ccc(Cl)cc2)[C@@H]1NC(=O)CF)(OCc1ccccc1)C([O-])=O |r|
Structure:
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