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Target
Protein Mdm4
Ligand
BDBM50327211
Substrate
n/a
Meas. Tech.
ChEMBL_664222 (CHEMBL1261729)
IC50
339000±n/a nM
Citation
 Datta, S; Bucks, ME; Koley, D; Lim, PX; Savinov, SN Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system. Bioorg Med Chem 18:6099-108 (2010) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50327211
Synonyms:
CHEMBL1256064 | tert-butyl (6S,9S,12S)-9-((1H-indol-3-yl)methyl)-1-amino-12-benzyl-1-imino-15,15-dimethyl-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-6-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C35H50N8O5
Mol. Mass.:
662.8221
SMILES:
CC(C)(C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OC(C)(C)C |r,wU:7.15,32.42,wD:18.31,(7.43,-28.91,;6.06,-29.72,;6.08,-31.27,;7.4,-30.48,;4.68,-28.94,;3.31,-29.75,;3.33,-31.35,;1.92,-28.97,;1.89,-27.43,;.83,-26.31,;1.25,-24.84,;.19,-23.73,;-1.31,-24.1,;-1.72,-25.58,;-.66,-26.69,;.59,-29.75,;-.75,-29,;-.77,-27.46,;-2.07,-29.79,;-2.05,-31.32,;-.71,-32.07,;.69,-31.44,;1.74,-32.57,;.98,-33.91,;1.47,-35.37,;.45,-36.52,;-1.06,-36.21,;-1.56,-34.76,;-.53,-33.61,;-3.42,-29.03,;-4.74,-29.82,;-4.72,-31.36,;-6.07,-29.06,;-6.1,-27.53,;-4.77,-26.74,;-4.79,-25.2,;-3.47,-24.41,;-3.49,-22.88,;-4.83,-22.12,;-2.15,-22.08,;-7.4,-29.85,;-8.79,-29.06,;-8.8,-27.5,;-10.13,-29.84,;-11.49,-29.08,;-12.82,-29.86,;-11.5,-27.52,;-12.84,-28.3,)|
Structure:
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