Reaction Details Report a problem with these data
Target
Plasmepsin II
Ligand
BDBM50071554
Substrate
n/a
Meas. Tech.
ChEBML_154921
Ki
90±n/a nM
Citation
Carroll, CD; Patel, H; Johnson, TO; Guo, T; Orlowski, M; He, ZM; Cavallaro, CL; Guo, J; Oksman, A; Gluzman, IY; Connelly, J; Chelsky, D; Goldberg, DE; Dolle, RE Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett 8:2315-20 (1999) [PubMed] Article
More Info.:
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
Inhibitor
Name:
BDBM50071554
Synonyms:
3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl-acetylamino)-pentanoylamino]-5-phenyl-pentanoic acid butylamide | CHEMBL309721
Type:
Small organic molecule
Emp. Form.:
C33H43N3O4
Mol. Mass.:
545.7122
SMILES:
CCCCNC(=O)CC(O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)Cc1ccc2ccccc2c1)[C@@H](C)CC