Compile Data Set for Download or QSAR
maximum 50k data
Found 1947 with Last Name = 'guo' and Initial = 't'
TargetKappa-type opioid receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50174573(CHEMBL3808477)
Affinity DataKi:  0.0330nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169371(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopropylmethyl-...)
Affinity DataKi:  0.170nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169377(1-[4-(3'-Cyano-biphenyl-4-yl)-1-propyl-piperidin-4...)
Affinity DataKi:  0.310nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169374(1-[4-(3'-Cyano-biphenyl-4-yl)-1-(2-methoxy-ethyl)-...)
Affinity DataKi:  0.410nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169390(1-[4-(3'-Cyano-biphenyl-4-yl)-1-isopropyl-piperidi...)
Affinity DataKi:  0.450nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169389(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopentyl-piperi...)
Affinity DataKi:  0.630nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317048(CHEMBL1097342 | N-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168805(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  0.840nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168812(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  0.880nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50174570(CHEMBL3808824)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169393(1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(3'-cya...)
Affinity DataKi:  0.980nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168825(1-(3-Chloro-4-fluoro-phenyl)-3-[2-(3'-cyano-biphen...)
Affinity DataKi:  0.980nMAssay Description:Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168825(1-(3-Chloro-4-fluoro-phenyl)-3-[2-(3'-cyano-biphen...)
Affinity DataKi:  0.980nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317056(CHEMBL1097349 | N-((1S,2S)-1-((R)-4-(3-chloropheny...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317055(CHEMBL1097348 | N-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317052(CHEMBL1097346 | N-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317051(CHEMBL1097345 | N-[(1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317060(CHEMBL1097353 | N-((1S,2S)-1-((R)-4-(benzylsulfony...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317027(CHEMBL1097321 | N1-((1S,2S)-3-(3,5-difluorophenyl)...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392835(CHEMBL2151181)
Affinity DataKi: <1nMAssay Description:Inhibition of human recombinant BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317058(CHEMBL1097351 | N-((1S,2S)-1-((R)-4-(5-chlorothiop...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317050(1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(...)
Affinity DataKi:  1nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168791(1-(3-Chloro-phenyl)-3-[2-(3'-cyano-biphenyl-4-yl)-...)
Affinity DataKi:  1.10nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169382(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclohexyl-piperid...)
Affinity DataKi:  1.20nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168800(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  1.20nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169396(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  1.40nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169376(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  1.40nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169386(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  1.5nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50392835(CHEMBL2151181)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50174571(CHEMBL3809310)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317059(CHEMBL1097352 | N-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataKi:  2nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271627(CHEMBL507651 | N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoi...)
Affinity DataKi:  2nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317057(CHEMBL1097350 | N-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataKi:  2nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169387(CHEMBL366703 | N-(4'-{4-[3-(3,5-Dichloro-phenyl)-u...)
Affinity DataKi:  2.10nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169388(1-(3,5-Dichloro-phenyl)-3-[1-methanesulfonyl-4-(4-...)
Affinity DataKi:  2.20nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169398(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  2.20nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168823(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  2.40nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169370(1-[4-(3'-Cyano-biphenyl-4-yl)-1-ethyl-piperidin-4-...)
Affinity DataKi:  2.60nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169392(1-[4-(3'-Chloro-biphenyl-4-yl)-1-methyl-piperidin-...)
Affinity DataKi:  2.60nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168802(1-[2-(3'-Cyano-biphenyl-4-yl)-4-methylamino-butyl]...)
Affinity DataKi:  2.60nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184924(1-((1S,2R,5S)-5-(4-cyanophenyl)bicyclo[3.1.0]hexan...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317049(CHEMBL1097343 | N-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataKi:  3nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50271626(CHEMBL509210 | N'-[(1S,2S)-2-[(2S)-4-benzyl-3-oxop...)
Affinity DataKi:  3nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168810(1-[2-(3'-Cyano-biphenyl-4-yl)-4-cyclopentylamino-b...)
Affinity DataKi:  3nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168810(1-[2-(3'-Cyano-biphenyl-4-yl)-4-cyclopentylamino-b...)
Affinity DataKi:  3nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317025(CHEMBL1097319 | N'-{(1S,2S)-1-(3,5-difluorobenzyl)...)
Affinity DataKi:  3nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317037(CHEMBL1097331 | N1-((1S,2S)-3-(3,5-difluorophenyl)...)
Affinity DataKi:  3nMAssay Description:Inhibition oh BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169391(1-(3,5-Dichloro-phenyl)-3-[1-methyl-4-(4-pyridin-3...)
Affinity DataKi:  3.10nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50174572(CHEMBL3809782)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50203355(3-(3-chloro-4-fluorophenyl)-1-((1R,3R,6S)-6-(3-cya...)
Affinity DataKi:  4nMAssay Description:Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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